Uses
The topical form of Estradiol is used in the treatment of specific indications of the onset of menopause, including urgency and irritation upon urination, dryness, itching on the vaginal area, and burning sensations.

How to take Estradiol
Estradiol is commonly available as a vaginal cream in a 42.5g tube, with a plastic applicator, or a 2mg vaginal ring. To apply the cream, use the marker in the applicator to measure the prescribed dose, then position the body so that easy access to the vaginal area is possible. Gently push in the applicator deep into the vagina, and press the plunger. To insert the ring, squeeze the sides and insert it into the vagina as far as possible. This should stay in its place for ninety days, and then removed and replaced, upon the direction of a physician.

Side effects
Adverse effects include dark spots on the skin, nausea and vomiting, withholding of excess fluid, enlargement or tenderness of the breasts, and enlargement of non-malignant tumors. Estradiol may also increase the chances of developing a condition which can lead to a cancer of the lining on the uterus. Taking progestrins can decrease such risks. Users should consult their doctor for any risks or benefits from the medication before they take on it.

Drug precautions
Women who are suspecting an onset of pregnancy are strongly discouraged from using any drug which contains estrogen. Administering Estradiol on conceiving women may lead to subsequent birth defects in the unborn child. Estradiol also does not prevent a miscarriage from occurring.

Drug interactions
Medications which may interact with Estradiol include wafarin; thyroid medications like levothyroxine; insulin and oral diabetes drugs, including glyburide, glipizide, and others; and tamoxifen.

Overdose
Incurring an overdose is not likely to occur with Estradiol; if it does, the threat to life is very minimal. If an overdose is suspected, or if the medicine is inadvertently ingested, contact a doctor or a poison center for immediate medical help.

Missed dose
In cases of a missed dose, administer the succeeding dose of the cream or ring upon remembering it. Proceed in following the regular schedule, and never administer two simultaneous doses of Estradiol without the prescription of a doctor.

Storage
Store Estradiol cream and ring within controlled room temperatures of 15°C and 30°C, away from excessive moisture and heat.